报告题目：Regioselective Pyridine C-H-Functionalization and Skeletal Editing
报告人：Armido Studer，国际知名有机化学家，自由基化学领域引领者，德国明斯特大学有机化学讲席教授。
时 间：2026年3月27日(周五)10:00
地 点：安徽大学磬苑校区材料科学大楼A101报告厅
主办单位：材料科学与工程学部
报告摘要：Pyridines belong to the most abundant heteroarenes in medicinal chemistry and in agrochemical industry. In the lecture, highly regioselective pyridine C-H functionalization through a dearomatization/rearomatization sequence will be discussed. The dearomatized oxazino pyridines can be easily prepared on a large scale, and meta-functionalization becomes achievable through light-initiated radical alkylation and ionic transformations.1 As example, using such an approach meta-fluorinated pyridines are readily accessible.2 The same intermediates upon protonation to give the corresponding pyridinium salts also allow the highly regioselective radical Minisci para-alkylation.3,4 In addition, Cu-catalyzed meta-arylation5 and switchable radical para/meta-difluoromethylation6 through such intermediates will be presented. Radical meta-nitration7 and ionic meta-hydroxylation8 work equally well through such intermediates. Finally, it will be shown that this dearomatization concept is also applicable to pyridine skeletal editing.9 Further, it will be discussed that an alternative radical dearomatization process can be used for C to N mutation in indoles and benzofurans.10
References
1. Cao, H.; Cheng, Q.; Studer, A. Science 2022, 378, 779. For a review, see: Bhattacharya, D.; Haring, M.; Studer, A. Chimia 2025, 79, 476.
2. Haring, M.; Balanna, K.; Cheng, Q.; Lammert, J.; Studer, A. J. Am. Chem. Soc. 2024, 146, 30758
3. Cao, H.; Bhattacharya, D.; Cheng, Q., Studer, A. J. Am. Chem. Soc. 2023, 145, 15581.
4. Wang, Z.; Xu, P.; Studer, A. Org. Chem. Front. 2024, 11, 3849.
5. Guo, S.-M.; Xu, P.; Studer, A. Angew. Chem. Int. Ed. 2024, 63, e202405385.
6. Xu, P.; Wang, Z.; Guo, S.-M.; Studer, A. Nat. Commun. 2024, 15, 4121.
7. Balanna, K.; Studer, A. J. Am. Chem. Soc. 2025, 147, 7485.
8. Bhattacharya, D.; Studer, A. Angew. Chem. Int. Ed. 2025, 64, e202423512.
9. Cheng, Q.; Bhattacharya, D.; Haring, M.; Cao, H.; Mück-Lichtenfeld, C.; Studer, A. Nat. Chem. 2024, 16, 741.
10. Wang, Z.; Xu, P.; Guo, S.-M.; Daniliuc, C. G.; Studer, A. Nature 2025, 642, 92.
Armido Studer简介： Armido Studer，国际知名有机化学家，自由基化学领域引领者，德国明斯特大学有机化学讲席教授。1995年获苏黎世联邦理工学院博士学位（师从Dieter Seebach教授），之后作为瑞士国家科学基金会博士后研究员在美国匹兹堡大学与Dennis P. Curran教授开展合作研究。1996年回到苏黎世联邦理工学院开启独立学术生涯，2000年起任德国马尔堡菲利普斯大学有机化学副教授，2004年受聘为明斯特大学有机化学讲席教授。2019年当选英国皇家化学会会士，2020年当选德国国家科学院院士，2021年当选欧洲人文和自然科学院院士。Studer教授是自由基化学复兴的核心推动者之一，学术贡献卓著，先后荣获莱布尼茨奖（2026）、阿道夫·冯·贝耶尔纪念奖章（2025）、Arthur C. Cope Late Career Scholars Award（2024）及英国皇家化学会佩德勒奖（2019）等多项国际重要奖项。累计发表高水平学术论文460 余篇，成果发表于Science、Nature、Nature Chemistry、Nature Synthesis等顶级期刊。
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